You are a doctor and have a patient who had a recent stroke….
Questions
Yоu аre а dоctоr аnd have a patient who had a recent stroke. The standard course of treatment is to prescribe Clopidogrel. Clopidogrel is a blood thinner that works by blocking platelet aggregation. The patient doesn’t seem to be responding to the medication. The FDA has labeled the medication with a warning that reads: DIMINISHED ANTIPLATELET EFFECT IN PATIENTS WITH TWO LOSS-OF-FUNCTION ALLELES OF THE CYP2C19 GENE You order genetic testing for your patient that reveals your patient is homozygous for mutations in the promoter region of the CYP2C19 gene. What is your interpretation of this result with regards to drug metabolism and dose?