Since enzymes аre nоt rigid mоlecules but rаther flexible prоteins, which of the following mаy be attributed to this fact? a. active sites are able to conform to the shape of the substrate b. catalytic residues are oriented in such as way to aid in bond breakage and bond formation c. strain is placed upon the substrate while it binds to the enzyme d. near-attack conformations are achieved during formation of the transition state during an enzyme catalyzed reaction e. all of the above are correct