The survival curve above is from a clinical trial testing…

Questions

  The survivаl curve аbоve is frоm а clinical trial testing the difference between 10 and 80 mg оf the statin drug Lipitor for the prevention of a Major Cardiovascular Event (MCE). The trial starts with ~5000 subjects in each group, and after 5 years of the trial we can see there are only 2300 individuals remaining in each group who are 'at risk'- a reduction of just over 50% (~2500 participants in each group). However, if we look closely at the survival curve, only about 10% of subjects (~500 per group) actually experienced an MCE. Using your knowledge of survival analysis, explain and provide some rationale for this apparent discrepancy... i.e. why is there such a dramatic difference in subjects who are no longer on trial because they experienced an MCE (~500 per group) vs. the total number who are no longer 'at-risk' (~2500 per group)?   

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