The fоllоwing stаtement is fаlse аbоut proton pump inhibitors: 1. They inhibit the proton pump by forming a covalent bond with the cysteine residues of H+/K+ ATPase.2. They are prodrugs with an acid resistant enteric coating.3. Their standard doses inhibit both basal and stimulated gastric acid secretion4. Pantoprazole is the prototype.5. Their long term use is associated with increased risk of fractures.