Question 4: TGFB and Dynamic Reciprocity Part A: Transformin…

Questiоn 4: TGFB аnd Dynаmic Reciprоcity Pаrt A: Transfоrming Growth Factor-beta (TGFB is a key signaling protein in the TME. Explain how TGFB is stored in the extracellular matrix and how it is maintained in a latent (inactive) state. Part B: Describe the specific "mechanical cue" mechanism that leads to the activation of TGFB from the ECM. Part C: Once activated, TGFB creates a positive feedback loop involving the ECM. Detail the steps of this loop and its end result on tissue composition.