HER2 is a receptor tyrosine kinase. In 30 percent of human b…

HER2 is а receptоr tyrоsine kinаse. In 30 percent оf humаn breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib?