Following oral administration of erlotinib, an anticancer dr…

Questions

Fоllоwing оrаl аdministrаtion of erlotinib, an anticancer drug with an oral bioavailability of 60%, 20% of the administered dose is recovered unchanged in the feces. Assuming negligible biliary excretion of unchanged drug and that all metabolism occurs in the liver, calculate the hepatic extraction ratio (ER) of erlotinib.