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RAG-1 and RAG-2 enzymes are expressed in almost all nucleated cells to rearrange the TCR and BCR variable region genes.

What is present during the first checkpoint in B-cell maturation?

Which of the following is true about the pre-B-cell?

Which cell types can become a plasma cell?

Which of the following is true about the pre-B-cell?

Which cell types can become a plasma cell?

In which of the following stages are the Ig genes for the light chain still in their germline configuration?

You would expect to see Igα and Igβ genes turned on (expressed) during the large pre-B cell stage.

Which gene segment is located within the α-chain locus and is consequently deleted and inactivated once the α gene rearranges it’s gene segments?

Once expression of RAG-1 and RAG-2 genes are turned on, expression is never turned off.