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A term infant with meconium aspiration syndrome (MAS) and severe persistent pulmonary hypertension of the newborn (PPHN) is critically ill on high-frequency oscillatory ventilation (HFOV) with 100% oxygen, inhaled nitric oxide at 20 ppm, and continuous infusions of vasopressin and epinephrine. Despite escalating support, the arterial blood gas shows significant metabolic acidosis, and urine output has been minimal over the past 8 hours. Blood pressure via umbilical arterial catheter is 45/20 mmHg (mean 35 mmHg). Chest radiograph demonstrates lung expansion to 9 ribs with a normal cardiothymic silhouette and diffuse patchy opacities. What is the most appropriate next step in management?

Coarctation of the aorta is commonly associated with an increased risk of:

Which of the following cyanotic defects will present with an enlarged heart and increased pulmonary congestion on chest xray?

What drug is contraindicated in the treatment of supraventricular tachycardia (SVT) in an infant with Wolff-Parkinson-White (WPW)?

What is the primary indication for immediate surgery in an infant born with an encephalocele?

A five-day old 28-week gestation infant is on a ventilator and has the following ABG: pH 7.15, PaCO2 65, PaO2 60, HCO3 16, base -8.  What is the correct interpretation of this ABG? 

Which of the following statements about congenital lobar emphysema is true?

You are counseling the parents of an infant who has been diagnosed with a meningocele. Which statement is true regarding this defect?

An inability to dispose of venous return on the right side of the heart will lead to:

Which of the following is most likely to be associated with neonatal seizures?