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Case Part 1: This is an unfolding case study. Clinical information will be provided in stages. Answer each question using only the information available at that stage. Select the single best answer. Ms. L is a 35-year-old woman diagnosed with Major Depressive Disorder.At baseline, she reported: Depressed mood Tearfulness Low motivation Anhedonia Poor concentration Fatigue She was started on sertraline and titrated appropriately. After 8 weeks, she reports: No longer tearful Mood “much better” Improved sleep However, she continues to experience: Low motivation Poor concentration Reduced interest in activities How should the clinician interpret this response?

A patient with depression reports persistent guilt and repetitive negative self-focused thoughts despite improvement in sleep and energy. Which region of the mood circuit most likely remains dysregulated?

A patient with bipolar II disorder is treated with an SNRI monotherapy for depressive symptoms. Within three weeks, she develops decreased need for sleep, increased goal-directed activity, and irritability. Which mechanism best explains this switch?

Match each medication in Column A with the most appropriate dominant symptom profile in Column B. Each option may be used once.

A patient with major depressive disorder is augmented with low-dose aripiprazole. Her motivation improves, but she develops mild akathisia. Which receptor-level activity best explains both findings?

Which symptoms are commonly present in both major depressive disorder and generalized anxiety disorder?(Select all that apply.)

Which of the following is associated with a higher BMR?

Sophia consumed 1800 kcals per day on a regular basis although her energy requirements are 2000 kcals per day. Sophia is theoretically _____.

Total energy expenditure is the total of:

In the 1980s, physicians Marshall and Warren discovered that the primary cause of most peptic ulcers was not stress or spicy food, but rather: