Mr. James, a 60-year-old man, is in the office today with hi…

Mr. James, a 60-year-old man, is in the office today with his wife after being referred to a neurologist by his primary care provider. The patient reports having a resting tremor in his right hand and some stiffness in the right area for over a year now. He thought the tremors were related to nerves and would eventually resolve on its’ own. He also doesn’t like going to the doctor and his wife finally convinced him to go. On inspection you notice a pill-rolling movement in his right hand at rest that resolves with active movement of the hand. On further inspection the relative slowness of fine rapid movements of the right hand are noted along with rigidity to the right arm. On the basis of the patient’s history and physical findings, the neurologist diagnosis is early-stage Parkinson’s disease. Answer the following questions based on this case.   1- Whatis the key neurotransmitter defect in Parkinson (1 point) and 2- Describe the usual role of the neurotransmitter? (1 points) 2- What areas of the brain are affected in Parkinson? (2 points) 3- Describe the symptoms that Mr. James has that are consistent with Parkinson’s disease ? (1 point)   

An 8 year old boy is brought in by his father and he is comp…

An 8 year old boy is brought in by his father and he is complaining of red, itchy eyes for 2 days. His father said it started in one eye and then got to the other. His eyes have a clear/mucous watery discharge which can sometimes be stringy. He denies eye pain but says he feels like he has sand in his eyes, he denies visual acuity change. He does have rhinitis, a productive cough with clear to yellowish phlegm, His father states his temp is about 99 F. His father says a lot of kids at his school have been sent home with colds this past week. NO history of asthma or allergic rhinitis or eczema. Allergies: NKDA Vital signs wnl General: WDWN 8 y/o boy in no acute distress Skin: pink, supple no lesions EENT: Canal clear, no vesicles; Tympanic membrane pearly gray, landmarks intact; nares with moderate amount whitish/tinge yellow discharge no oral lesions, no pharyngeal edema, Eyes: Bilateral edematous eyelids, clear, mucous drainage on lashes, conjunctiva erythematous, injected. Cornea and eyelid margins, no ulceration. PERRL bilaterally, OS 20/20, OD20/20. Fundoscopic well marginated discs, no AV nicking 1- What is the most likely type of conjunctivitis in this patient? (1) 2-  Discuss why you chose this answer (2 points) 3- What is a common organism in this type of conjunctivitis? (1) 4-How are infections acquired, what is the mode of transmission? (1 point)

According to the Congressional Research Service, In April 20…

According to the Congressional Research Service, In April 2020, the unemployment rate reached 14.8%—the highest rate observed since data collection began in 1948. In July 2021, unemployment remained higher (5.4%) than it had been in February 2020 (3.5%).   This statement offers an example for which of the following concepts? 

Question 3: Stepwise Regression – 13 points For this questio…

Question 3: Stepwise Regression – 13 points For this question, use the unstandardized data (trainData).             a. Perform forward stepwise regression using BIC. Let the minimum model be the one with only an intercept, and the  maximum model to be model1. Display the model summary of your final model. Call it forward_model. (2 points) NOTE: For R, keep the max iteration of 1000 when running the step function. NOTE: For Python, keep the max iteration of 1000 when running the stepwise function.   Which variables were selected in the forward_model? Which regression coefficients are significant at the 99% confidence level in forward_model? (1.5 points) At which BIC value did the model cease selecting predictors, and what was the reason for this? (1.5 points) b. Perform forward-backward stepwise regression model using AIC, starting with intercept-only model. Call it both_model. (1 point) NOTE: For R, keep the max iteration of 1000 when running the step function. NOTE: For Python, keep the max iteration of 100 when running the stepwise function.   i) Which variables are selected in both_model? (1 point) ii) Are all the selected variables significant at 99% level? Explain the reason. (1.5 points) iii) If any variable is not significant at 99% level, why might it still be included? (1.5 points) c. Perform 2 Partial F-tests to compare the both_model (3b) with the full model (model1) and the forward model with model1. What is your interpretation at the 95% confidence level? (2 points) d. What is the difference in variable selection between forward, backward and forward-backward stepwise regresssion? (1 point)