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Imagine you’re a doctor and you discover that your patient, a recently born infant, has thrush. You order genetic sequencing and find that the RAG-1 gene doesn’t produce a functional enzyme.  From what you have learned in this class and with this information at hand, you can conclude that:

Which cell(s) would you expect to see RAG-1 and RAG-2 expressed in during maturation?

How many HVs (hypervariable regions) does one TCR contain?

The MHC Class I molecule has an α chain and β chain, whereas the MHC Class II molecule has an α chain noncovalently bound to a β2-microglobulin.

You would expect the Igα and Igβ genes to be turned off (not expressed) during which stage(s)?

Which of the following is false about anergic B-cells?

An extracellular antigen that is taken up from the extracellular space will be degraded into peptides, and loaded onto MHC Class II in an endosome (phagolysosome).

Which of the following component(s) would be part of the CD3 complex?

Every human expresses thousands of MHC molecules and each MHC molecule is specific for a single antigenic peptide.

To find the distance to the moon, humans first had to find the size of the earth.  So they knew the radius of the earth (about 4000 miles) and they also were able to measure angle E.  Hence, using the figure above, what is the equation used to find the distance from the center of the earth to the moon?