You are interested in collecting Circulating Tumor Cells (CT…

You are interested in collecting Circulating Tumor Cells (CTCs) from a cancer patient to track tumor recurrence. What is the most recent (last) step in the process of metastasis (the Invasion-Metastasis cascade) that a cancer cell must have completed in order to be a CTC?

In 2016, Novartis received FDA approval to use LEE011 (riboc…

In 2016, Novartis received FDA approval to use LEE011 (ribociclib), in combination with letrozole, for the treatment of HR+ HER2– breast cancer. LEE011 is a specific inhibitor of G1 CDK complexes. Reduced phosphorylation of which of the following proteins best explains the underlying mechanism of the antineoplastic activity of LEE011?