You are in craniofacial clinic counseling the parents of a y…

You are in craniofacial clinic counseling the parents of a young girl with cleft lip and palate, a condition more common in males. She is growing and developing well and has no other congenital anomalies. A second cousin once removed was also affected, but the family history is otherwise negative. Which of the following is TRUE regarding the chance that their next child will have cleft lip and palate?

An autosomal locus is paternally imprinted (paternal copy is…

An autosomal locus is paternally imprinted (paternal copy is shut off) and is associated with a genetic disorder that is due to complete loss of gene expression from that locus. Which one of the following scenarios is MOST likely to be causative of the genetic disorder?