LM is a 41-year-old female who presents to the HIV clinic wi…

LM is a 41-year-old female who presents to the HIV clinic with a new diagnosis of HIV.  Her past medical history is significant for hypertension.  She has no known allergies.  Her labs today reveal a CD4 count of 35 cells/mm3 and viral load of 129,000 copies/ml.  What antimicrobials would be beneficial for this patient?

Donal has metastatic NSCLC and will be treated with carbopla…

Donal has metastatic NSCLC and will be treated with carboplatin (AUC 5) and pemetrexed (500 mg/m2/dose). Donal is 70 inches tall and weighs 180 pounds. Calculate the pemetrexed dose for Donal [dose1] mg and volume of drug needed [dose2] mL. Pemetrexed is available as a 500-mg powdered vial and requires injecting 20 mL 0.9% sodium chloride to prepare the medication.

BR is a 78-year-old man who diagnosed with Hodgkin’s Lymphom…

BR is a 78-year-old man who diagnosed with Hodgkin’s Lymphoma. and started on induction chemotherapy, resulting in an absolute neutrophil count of 60 cells/mm3, which is expected for at least the next 7 days.  His Tmax spikes to 101.9⁰F on day 3 with blood pressure 90/59 mm Hg and respiratory rate 24 breaths/min. Blood cultures are pending.  The team wants an antimicrobial recommendation for this patient.  What should you recommend? 

RS is 31 -year-old male who is HIV positive.  At his last vi…

RS is 31 -year-old male who is HIV positive.  At his last visit 6 months ago, he was stable with a CD4 count of 375 cells/mm3 and viral load of 10,000 copies/ml and refused to take any anti-retroviral therapy.  He urgently presents to the clinic today with mild symptoms of shortness of breath, fever and cough.  His laboratory studies at this visit reveal a CD4 count of 175 cell/mm3 and viral load of 175,000 copies/ml.  He states that he is allergic to sulfa but does not know the reaction.  His chest x-ray is consistent with Pneumocystis jerovici pneumonia.  His provider wants to start therapy.  What first line therapy would you recommend?