A regional healthcare system notes rising rates of multidrug…

A regional healthcare system notes rising rates of multidrug-resistant organisms, including extended-spectrum beta-lactamase (ESBL)–producing Enterobacterales. Leadership is developing a strategy to directly reduce further antimicrobial resistance within the institution. Which intervention is most likely to have the greatest immediate impact on slowing antimicrobial resistance?

A 46-year-old patient presents for hypertension follow-up. D…

A 46-year-old patient presents for hypertension follow-up. Despite adherence to maximally tolerated doses of an ACE inhibitor, a calcium channel blocker, and a thiazide diuretic, the patient’s blood pressure remains 158/96 mm Hg. Laboratory evaluation reveals mild hypokalemia. The provider is considering secondary causes of hypertension.Which patient scenario warrants screening for primary hyperaldosteronism?

A 6-year-old child presents with fever, sore throat, and a d…

A 6-year-old child presents with fever, sore throat, and a diffuse erythematous rash that feels like sandpaper. Physical examination reveals a strawberry tongue, circumoral pallor, and tender anterior cervical lymphadenopathy. Rapid antigen detection testing for Group A Streptococcus is positive.What is the most appropriate initial treatment?

A 48-year-old patient reports a 6-month history of uncomfort…

A 48-year-old patient reports a 6-month history of uncomfortable sensations in both legs occurring primarily in the evening. The patient describes an urge to move the legs that worsens at rest and improves temporarily with walking. Sleep has become fragmented as a result. Physical examination is normal. What is the most appropriate initial management step?

A 28-year-old nonpregnant woman presents with fever (101.8°F…

A 28-year-old nonpregnant woman presents with fever (101.8°F), flank pain, nausea, and dysuria. Urinalysis shows pyuria and bacteriuria. The clinician plans outpatient treatment after giving an initial dose of ceftriaxone. Which oral antibiotic regimen is most appropriate for continued therapy?