Category: Uncategorized

Which of the following is a disease-oriented outcome?

A non-inferiority study compared risankizumab (intervention) to secukinumab (standard of care) for at least 90% improvement in plaque psoriasis symptoms. An NI margin of 12% was used. Risankizumab was found to achieve a 90% symptom improvement in 73.8% of patients and in secukinumab 65.6% of patients.  95%CI 0.8 to 38.8%). Which of the following is the best interpretation of these results. Compared to secukinumab:

The following 4 scenarios are all from double-masked RCTs. Which of the following situations would be at the highest risk for decreased internal validity due to compromised masking?

What is the current labled with a “?” if 6, 8, 3 and 4?

A study compared an extended interval between zolendronic acid infusions (every 12 weeks) for preventing skeletal lesions among patients with cancer to the standard of care (every 4 weeks). The NI margin was an absolute difference of 0.28% in the skeletal morbidity rate. Which of the following is the null hypothesis for this study?

A RCT compared occurrence of flares in patients with gout. The results showed febuxostat compared with allopurinol resulted in a HR of 1.07 (95%CI 1.02–1.09). Which of the following statements best describes the interpretation of these results?

Itepekimab was compared to placebo in a RCT for use in patients with moderate-to-severe atopic dermatitis (i.e. severe skin inflammation and itching). The primary outcome was changes in the Eczema Area and Severity Index (EASI) score which has a minimally clinically important difference of a change in at least 6.6 points. At week 16 in the RCT, itepekimab had a mean decrease in the EASI score of 14.2 points compared to placebo (p=0.12).

A battery with EMF of 30 V and negligible internal resistance is connected to a resistor network as shown. Before the switch is closed, a current is delivered by the battery. After the switch is closed, a current is delivered by the battery. Find

It is estimated that angioedema occurs in approximately 0.1% of patients taking losartan. An investigator would like to identify potential risk factors for patients who experience angioedema while taking losartan. Which of the following study designs would be most appropriate?

A new antihistamine, metalazine, is compared to placebo for mild-to-moderate seasonal allergies. An allergy symptom visual analog scale of 0, meaning no symptoms, to 10, meaning the worst symptoms imaginable is used as the primary outcome. Metalazine was found to decrease the allergy symptoms visual analog scale by 3.2 points (95%CI -0.4 to 7.8). Which of the following statements best describes the potential type of statistical error present in this study?