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Question 10 (26 points total). SN1 mechanism. part A (18 points). Give a detailed curved-arrow electron-pushing mechanism for the reaction shown below. Label the Lewis acid/base (LA/LB) and Bronsted acid/base (BA/BB; if applicable) for each intermolecular step. part B (2 points). GIVE THE NUMBER OF SETS OF INTERMEDIATES AND THE NUMBER OF TRANSITION STATES for your mechanism. part C (6 points). Draw a reaction energy diagram for your mechanism. Indicate (label) the activation energy for the Rate Determining Step. To preview image: Click HERE      

A woman develops hypotension with tachycardia after spinal anaesthesia for caesarean section. Which drug is considered first-line treatment?

A caudal block is being considered for perioperative analgesia. Which patient group most commonly benefits from this technique?

Which anatomical structure is intentionally penetrated during spinal anaesthesia but not during epidural anaesthesia?

A 24-year-old woman with asthma is scheduled for elective surgery. She reports night-time wheezing and increased use of her salbutamol inhaler over the past week. Pulmonary function testing shows an FEV1 of 55% predicted, with improvement after inhaled bronchodilator. What is the most appropriate preoperative management?

A 58-year-old man is scheduled for elective hernia repair. He has well-controlled hypertension and type 2 diabetes mellitus, with no limitation of daily activities. He walks up two flights of stairs without chest pain or shortness of breath. What is the most appropriate ASA physical status classification?

A trauma patient receives large volumes of crystalloid fluid during resuscitation. Which complication may occur as a result from the fluid?

A child requires inhalational induction of anaesthesia. Which fast acting volatile anaesthetic agent is commonly used for inhalational induction?

A woman requires spinal anaesthesia for caesarean section. Which local anaesthetic preparation is preferred?

During general anaesthesia, the capnograph baseline does not return to zero and the inspiratory CO₂ reading is raised. What is the most likely explanation?