Assume the gene encodes a 300-amino-acid enzyme, no alternat…

Assume the gene encodes a 300-amino-acid enzyme, no alternative start codon is used, and the catalytic residue is essential. Classify the predicted functional disruption using all information in each row.A synonymous change occurs in the final third of the coding region and does not alter splicing. [row1]A one-nucleotide deletion occurs at codon 2. [row2]Three nucleotides are inserted into a flexible, nonconserved tail, and activity falls to 60 percent. [row3]A missense mutation changes the catalytic residue and leaves less than 5 percent activity. [row4]A conservative surface substitution leaves 85 percent activity. [row5]A nonsense mutation at codon 240 removes a regulatory tail but preserves the catalytic domain. [row6]

How many data points (n) are needed for a 4th-order Newton p…

How many data points (n) are needed for a 4th-order Newton polynomial interpolation? If xi =1, 1.5, 2, 2.5, 3, 4, 4.5, 5, 5.5, 6 and the corresponding f(xi) values are given, which values of xi would you select to estimate f(3.2) using a 4th-order Newton polynomial interpolation? Specify the selected values as x1, x2, …, xn                                                   (3 points)   2. The corresponding values of f(x) are provided at the following points: x=0, 1, 2, 3, 3.5, 4, 4.5, 5, 5.5, 6 Assuming that only Simpson’s rules may be used for numerical integration, explain how you would approach the evaluation of the integral over the given interval (0 to 6). Clearly indicate which Simpson’s rule(s) you would apply to each section and justify your choice.                      (3 points)   Construct amplitude and Phase line spectra for the following function. ​             for k = 1, 3, 5, 7                        (4 points)