A 58-year-old works in construction and has years of unprote…

A 58-year-old works in construction and has years of unprotected noise exposure. He complains of persistent high-pitched ringing in both ears, worse at night. Otoscopic exam is normal. Audiometry shows high-frequency hearing loss. You explain that the most common mechanism relates to peripheral auditory damage, with downstream central “gain” changes contributing to the perception of sound without an external stimulus. Tinnitus most commonly results from:  

A 58-year-old with cellulitis due to Gram-positive cocci is…

A 58-year-old with cellulitis due to Gram-positive cocci is started on an antibiotic that binds penicillin-binding proteins (PBPs) and prevents cross-linking of peptidoglycan. Within 48 hours, erythema and warmth improve. The student asks which class specifically targets cell wall synthesis. Which antimicrobial mechanism disrupts bacterial cell wall synthesis?