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Match the presenting symptoms with the most likely related neoplasm.

A 72‑year‑old with prostate cancer is observed to have sclerotic bone metastases without liver lesions on CT scan. What explains this finding?

A 57‑year‑old woman with obesity, pre‑diabetes, and a strong family history of breast and colon cancer begins a structured exercise program after counseling in your clinic. She now performs brisk walking 40 minutes/day, 5 days/week, plus resistance training twice weekly.  Which of the following are cellular effects of this type of regular exercise? (SELECT ALL)

A 55‑year‑old with breast cancer shows tumor cells down‑regulating MHC‑I. Which immune effector becomes most important?

 A patient is being treated a medication, trastuzumab, which is beneficial because it helps the NK‑cell CD16 bind to IgG‑coated tumor cells. What is this physiological process of the NK-cells called?

What is the primary role of caretaker genes in maintaining normal cellular function?

Which statement best explains the “two-hit hypothesis” in developing cancer?

An online order entry process runs continuously throughout the day. A monthly sales summary process runs on the last day of each month using the same sales data. How should these processes be partitioned?  

Connecting a data store directly to an external entity is:

A context diagram: