A wheezing 65 year old female with a history of asthma prese…

A wheezing 65 year old female with a history of asthma presents with renal failure. The eosinophil count is markedly elevated. A renal biopsy shows necrotizing glomerulonephritis with cellular crescents and little to no staining for immunoglobulins and complement on immunofluorescence. What is the most likely diagnosis?

The aldosterone receptor inhibitor spironolactone is conside…

The aldosterone receptor inhibitor spironolactone is considered a potassium-sparing diuretic. Given what you know about the site of aldosterone action in the nephron, which nephron segment(s) and sodium transporter(s) might be affected by spironolactone treatment?