A 37-year-old woman is extroverted, dresses provocatively, a…

A 37-year-old woman is extroverted, dresses provocatively, and demands to be at the center of attention. She says she is upset because her work supervisor recently reprimanded her for wearing “suggestive clothing” and flirting with coworkers. This pattern of behavior has been consistent since early adulthood. Throughout today’s office visit, she appears excessively emotional and flirtatious, and exhibits animated gesturing. Given the likely diagnosis, which of the following statements is most consistent with this patient’s condition?

A 42-year-old man with schizophrenia presents to the clinic…

A 42-year-old man with schizophrenia presents to the clinic for follow-up. He was recently switched from olanzapine to ziprasidone due to excessive weight gain and metabolic side effects. He reports feeling well overall with no worsening of psychiatric symptoms. His medical history is significant for hypertension and hyperlipidemia. He does not use alcohol or illicit drugs. On examination, his vital signs are within normal limits. A 12-lead electrocardiogram (ECG) reveals a QTc interval of 490 ms (normal: < 450 ms). Laboratory results,  including serum electrolytes and renal function, are unremarkable. What effect of ziprasidone is responsible for the EKG finding?