Which of the following statements regarding the visceral or unitary smooth muscle is NOT true?
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The first-generation sulfonylurea drug chlorpropamide has a…
The first-generation sulfonylurea drug chlorpropamide has a half-life of 25-60 hours and a duration of glycaemic effect of 24-72 h. The structurally related analogue, tolbutamide, has a much shorter duration of action, around 6-24 h. a. With reference to the structures of the two compounds, and drug metabolism, suggest why chlorpropamide displays longer-lasting effects than tolbutamide. (3 marks) b. Clinical signs of hypoglycaemia developed in a 3-year-old boy 24 hours after he had mistakenly eaten some of the pretty blue-coloured chlorpropamide tablets, thinking they were sweets. Given that chlorpropamide is an acidic drug with a pKa of ~5.2, suggest an approach to treat the patient through enhanced elimination of the drug, with rationale. (2 marks)
Which aromatic / heterocyclic system is found within the ant…
Which aromatic / heterocyclic system is found within the anticoagulant drug, warfarin?
PJ, a 60-year-old woman, has just been rushed to the Emergen…
PJ, a 60-year-old woman, has just been rushed to the Emergency Department with a chief complaint of crushing chest pain that keeps radiating to her lower jaw, left shoulder and arm. Initial management of AJ’s presenting condition is likely to include all the following, EXCEPT:
Which of the following is the first step in the sliding fila…
Which of the following is the first step in the sliding filament mechanism of muscle contraction?
A 68-year-old patient is prescribed dabigatran capsules for…
A 68-year-old patient is prescribed dabigatran capsules for the prophylaxis of VTE following a total knee replacement. How many dabigatran 110 mg capsules will you need to supply to cover the full course? Extract from Online BNF
Which of these are elements of a metes and bounds land descr…
Which of these are elements of a metes and bounds land description? (Choose all correct answers)
____________________ is a way in which title to a property c…
____________________ is a way in which title to a property can transfer without consent or knowledge of the prior owner, and without a deed.
While ___ ATP molecules can theoretically be produced from 1…
While ___ ATP molecules can theoretically be produced from 1 glucose during aerobic respiration, ___ ATP molecules are produced via fermentation of 1 glucose.
The legal character of real estate brokerage has gone throug…
The legal character of real estate brokerage has gone through challenges in recent decades. Statements that accurately describe the real estate brokerage relationship in recent years include which of these? (Choose all correct answers)