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Which of the following statements regarding drug metabolism is INCORRECT?

PB attends for his annual medication review with you, a pharmacist working in general practice. Which ONE of the following assessment tools could be used to predict PB’s risk of developing cardiovascular disease?

Helen Hunt Jackson’s A Century of Dishonor:

The only black man during Reconstruction elected to a full term in the U.S. Senate was:

What was the name of the women’s group that organized to make liquor illegal?: 

A solution of a drug (101.51 ppm) and internal standard (206.12 ppm) are injected onto a gas chromatograph. The peak area of the drug is determined to be 12541, and the peak area of the internal standard is 17889. What is the relative response factor (RRF)?

A 200 mg dose of a drug was given IV to a patient and a blood sample was taken shortly afterwards. The initial concentration of the drug in the plasma was measured as 560 μg/mL. Calculate the apparent volume of distribution (Vd) in litres.

Which of the following statements regarding the visceral or unitary smooth muscle is NOT true?

The first-generation sulfonylurea drug chlorpropamide has a half-life of 25-60 hours and a duration of glycaemic effect of 24-72 h. The structurally related analogue, tolbutamide, has a much shorter duration of action, around 6-24 h.     a. With reference to the structures of the two compounds, and drug metabolism, suggest why chlorpropamide displays longer-lasting effects than tolbutamide. (3 marks) b. Clinical signs of hypoglycaemia developed in a 3-year-old boy 24 hours after he had mistakenly eaten some of the pretty blue-coloured chlorpropamide tablets, thinking they were sweets. Given that chlorpropamide is an acidic drug with a pKa of ~5.2, suggest an approach to treat the patient through enhanced elimination of the drug, with rationale. (2 marks)

Which aromatic / heterocyclic system is found within the anticoagulant drug, warfarin?