Which pharmacologic property explains why some COX-2 selecti…

Which pharmacologic property explains why some COX-2 selective NSAIDs increase cardiovascular risk?   Enhanced platelet inhibition similar to aspirin   Reduced prostacyclin production leading to prothrombotic effects   Increased renal prostaglandin synthesis causing hypertension   Increased thromboxane A2 production from platelets 

That all is as thinking makes it so—and you control your thi…

That all is as thinking makes it so—and you control your thinking.  So remove your judgements whenever you wish and then there is calm—as the sailor rounding the cape finds smooth water and the welcome of a waveless bay. Meditations, 12.22, page 119 [Hammond translation]