A specific T-cell receptor will only recognize a peptide pre…

A specific T-cell receptor will only recognize a peptide presented by a specific MHC molecule but will not recognize a different peptide presented by the same MHC molecule or the same peptide presented by a different MHC molecule. The T-cell recognition of antigen is said to be:

Imagine you are a doctor and you discover your infant patien…

Imagine you are a doctor and you discover your infant patient has a missense mutation of the RAG proteins which leads to partial enzymatic activity of RAG enzymes which leads to symptoms that show as autoimmunity.  Based on what we have discussed in class, you conclude that: