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The decreased response to a drug that develops after repeated doses are given is known as ____.

Marianne, 62 years of age, is discussing osteoporosis prevention with her doctor, with concerns about the action of estrogen replacement on breast and uterine tissue. Marianne might be interested in selective estrogen-receptor modifiers (SERMs) because they have an estrogen ____.

Zach normally takes an antianxiety medication and, after he has his wisdom teeth pulled, takes a narcotic pain medication as well. He suddenly finds himself very drowsy and disoriented. This is an example of ____.

Parker is instructed to drink lots of fluids while taking colchicine for an acute gout attack. Why?

Patrick, who has bipolar disorder, has a history of serious suicide attempts. What mood stabilizer is successful in reducing suicide rates in persons with bipolar disorder?

Marcy is receiving cisplatin for the treatment of ovarian cancer.  Cisplatin acts by _____.

Zach has Crohn’s disease. His doctor has prescribed a salicylate to help reduce inflammation. What drug is he likely taking?

You are taking an upcoming trip to Asia. Because you typically have motion sickness on long flights, you “get the patch.” What drug is likely to be in the patch?

Luis has severe, active inflammatory bowel disease that has not not adequately treated with salicylates. What type of drug might be tried next?

Your best friend is diagnosed with lymphoma and asks you about what she’s read about the side effects of treatments, particularly gastrointestinal effects and hair loss. You explain to her that many drugs used in the treatment of cancer have effects on the gastrointestinal system and hair because they are especially toxic to cells that are ____.