The compound rotenone has seen wide use as a rat poison. As…

The compound rotenone has seen wide use as a rat poison. As an inhibitor, rotenone binds and blocks electron transport at Complex I of the electron transport chain (ETC). What are the consequences to electron transport when this inhibitor is introduced into cells?

In an experimental system for the study of the electron tran…

In an experimental system for the study of the electron transport chain, electrons can be supplied by adding ascorbate as an artificial electron donor. When using ascorbate in these experiments it is necessary to include an electron acceptor such as TMPD (an intermediate electron acceptor) that accepts electrons from ascorbate and can then donate electrons to cytochrome c. When using this experimental system it would be possible to transfer electrons directly to which complex?

Crib death of infants when fasting (i.e., when sleeping and…

Crib death of infants when fasting (i.e., when sleeping and not eating – therefore a low blood glucose condition) is also known as sudden infant death syndrome (SIDS). SIDS was often blamed on lack of proper care by the parents of the child. It is now known that a significant number of SIDS cases are caused by a genetic defect in the gene that codes for fatty acyl-CoA dehydrogenase, the enzyme that catalyzes the first step in fatty acid β-oxidation (see question 34 for this reaction). If this enzyme is defective, energy from fatty acids is not available and, in addition, gluconeogenesis is inhibited resulting in severe and life-threatening hypoglycemia (low blood glucose). Why the hypoglycemia?

Glucagon released during periods of low blood glucose among…

Glucagon released during periods of low blood glucose among its other effects also activates the gene transcription for the gene that encodes phosphoenolpyruvate carboxykinase. The carbon flux through which pathway will be increased by increased levels of glucagon?