As discussed in this section, mutations in the LDL receptor…

As discussed in this section, mutations in the LDL receptor can cause familial hypercholesterolemia. However, mutations in apolipoprotein B100 have also been discovered that cause hypercholesterolemia. For example, mutation of arginine-3500 to glutamine (R3500Q) in apolipoprotein B100 was one of the first such mutations. Which of the following is an appropriate hypothesis for how apolipoprotein B100 mutations cause hypercholesterolemia?