The Pyruvate Dehydrogenase Complex converts pyruvate into Ac…

The Pyruvate Dehydrogenase Complex converts pyruvate into Acetyl CoA and then determines whether this molecule will enter into the TCA cycle or continue on to Fatty Acid Synthesis. Regulation includes: Allosteric feedback inhibition from [drop1] which blocks dihydrolipoyl transacetylase and [drop2] which inhibits dihydrolipoyl dehydrogenase. Covalent modification deactivates Pyruvate Dehydrogenase by means of a [drop3] enzyme and reactivates it by means of a [drop4] enzyme. Finally, [Drop5] activates pyruvate dehydrogenase and [drop6] inhibits it.