One of your colleagues shows you these images of cross-secti…

One of your colleagues shows you these images of cross-sections from control (A) and mutant (B) E10.5 mouse embryos with a dotted line surrounding the DRG. The sections were incubated with a probe that labels activated Caspases (the dark product). Deletion of which gene would most likely result in the relative increase in caspase activation seen in the mutant DRG in B?  

Hirschsprung disease (aka congenital aganglionic megacolon)…

Hirschsprung disease (aka congenital aganglionic megacolon) stems from a failure of enteric nervous system (ENS) innervation of the distal colon resulting in the inability to pass stool. Scientists studying this disease are interested in modeling the ENS in culture  beginning with human iPSCs. Considering what we know about the developmental pathway leading to ENS cells, what cell type would the scientist need to first differentiate the iPSCs into prior to generating ENS cells?