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A 46-year-old patient presents for hypertension follow-up. Despite adherence to maximally tolerated doses of an ACE inhibitor, a calcium channel blocker, and a thiazide diuretic, the patient’s blood pressure remains 158/96 mm Hg. Laboratory evaluation reveals mild hypokalemia. The provider is considering secondary causes of hypertension.Which patient scenario warrants screening for primary hyperaldosteronism?

A 6-year-old child presents with fever, sore throat, and a diffuse erythematous rash that feels like sandpaper. Physical examination reveals a strawberry tongue, circumoral pallor, and tender anterior cervical lymphadenopathy. Rapid antigen detection testing for Group A Streptococcus is positive.What is the most appropriate initial treatment?

A 48-year-old patient reports a 6-month history of uncomfortable sensations in both legs occurring primarily in the evening. The patient describes an urge to move the legs that worsens at rest and improves temporarily with walking. Sleep has become fragmented as a result. Physical examination is normal. What is the most appropriate initial management step?

Which process most commonly leads to uncomplicated urinary tract infections in female patients?

A 59-year-old man reports erectile dysfunction and is taking sertraline for depression and a thiazide diuretic for hypertension. He asks what might be contributing. Which statement is most accurate?

A patient has an abnormality of kidney function lasting 6 weeks. They do not meet AKI (acute kidney injury) criteria but have an eGFR of 55 mL/min/1.73 m² with implications for health. Which classification best fits this presentation?

A 76-year-old man presents with decreased urine output and suprapubic fullness. Which etiology of acute kidney injury (AKI) is most likely?

A 28-year-old nonpregnant woman presents with fever (101.8°F), flank pain, nausea, and dysuria. Urinalysis shows pyuria and bacteriuria. The clinician plans outpatient treatment after giving an initial dose of ceftriaxone. Which oral antibiotic regimen is most appropriate for continued therapy?

A provider wants the preferred screening strategy for albuminuria in primary care. Which is best?

Which diagnostic test is recommended for screening chlamydia and gonorrhea?