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The drugs acetaminophen (Tylenol), diphenhydramine (Benadryl), and warfarin (Coumadin) all exhibit very different biological and/or pharmacological activity. Therefore, they ______ the same pharmacophore.

Consider the compound Elamipretide shown here. ENTER A, B, C, D, E or NONE to complete the blanks… *** a) Region(s) [blank1] is/are considered polar *** b) Region(s) [blank2] is/are considered lipophilic *** c) Region(s) [blank3] include(s) the amino acid Valine *** d) Region(s) [blank4] include(s) the amino acid Phenylalanine *** e) Region(s) [blank5] will ionize greater than 50% at pH 7.4 SHORT ANSWER… *** f) What types of bonds present in Elamipretide would readily hydrolyze under acidic conditions? Briefly explain… [blank6] *** g) What would the NET CHARGE be on Elamipretide at physiolgical pH, 7.4? Briefly explain… [blank7]

Select the amino acid(s) that contain an IONIZABLE SIDE CHAIN (under physiological conditions)? (select all that apply)

Consider Drug S in the figure below. Which functional group is most sensitive to ACID DEGRADATION?

Select the amino acid(s) that contain a POLAR SIDE CHAIN? (select all that apply)

The following statements are ALL FALSE. CORRECT THE STATEMENTS *** Alkaloids like quinine are biologically active amine-containing compounds typically found in animals [blank1] *** The DNA/RNA base shown here is categorized as a pyrimidine [blank2] *** The functional groups show here is acidic under physiological conditions [blank3] R-O-R’ *** The drug shown below is the sodium salt of penicillin [blank4]

Refer to Drug Y for this question. Determine if the statements regarding Drug Y are either TRUE or FALSE.  

Recalling discussions regarding “what’s in a drug name?”, of the functional groups listed below, select the group(s) that are likely to be present in a drug named CHLORAMPHENICOL? (select all that apply)

Consider the binding site within the muscarinic receptor where the endogenous neurotransmitter Acetylcholine binds. If the structure of Acetylcholine were redrawn properly within the active site, match the functional groups (1-6) to the locations in the binding site (A-F) where they would interact. (hint: rotate, twist, flip, turn the molecule as needed…expand combined functional groups as necessary). Functional Group # Binding Site Location (1) methyl group ? (2) oxygen in carbonyl between (A) and (B) (3) oxygen in ester ? (4) two-carbon spacer between (E) and (F) (5) quaternary amine ? (6) three methyl groups ?   note: Tyr616 has an -OH side chain

Identify the amino acid(s) with a side chain that participates primarily in hydrophobic interactions  at physiological pH (7.4). (select all that apply)