A 25-year-old man with idiopathic generalized epilepsy with…

A 25-year-old man with idiopathic generalized epilepsy with generalized tonic-clonic seizures, continues to have breakthrough seizures despite being on maximally tolerated doses of lamotrigine. Sodium valproate is added to his treatment regimen. Which of the following effects may result from interaction between these drugs?

Mrs AB is a 56-year-old patient who has a history of epileps…

Mrs AB is a 56-year-old patient who has a history of epilepsy. She has been poorly controlled recently and her neurologist has initiated her on phenytoin. She was initially prescribed a dose of 300mg daily, however her dose has recently been increased to 350mg daily. Shortly following this dose increase she began to experience symptoms of phenytoin toxicity. Explain why small dose increments with phenytoin can result in toxicity? (5 Marks)