A newborn patient weighing 2.8 kg is prescribed alprostadil…

A newborn patient weighing 2.8 kg is prescribed alprostadil at a dose of 3 mcg/kg/hour. The alprostadil infusion to be used contains 300 mcg of alprostadil in 50 mL of glucose 5 %. At what rate in mL/hour should the infusion be administered? Give your answer to ONE (1) decimal place.

You are working as a pharmacist independent prescriber in an…

You are working as a pharmacist independent prescriber in an urgent care centre. You examine a 28-month-old child who you diagnose with otitis media. They have been unsettled and have been pulling on their ear for the last three days. As the patient is allergic to penicillin (widespread rash), you decide to prescribe erythromycin 250 mg/5 mL suspension FOUR times a day for five days. How many millilitres of erythromycin 250 mg/5 mL oral solution should be prescribed for the full treatment duration?   Extract from the Online BNF

Mrs TR (weight 60 kg) is 56 years old with a history of smok…

Mrs TR (weight 60 kg) is 56 years old with a history of smoking and COPD. She is admitted to the respiratory ward after an appointment with the GP. She is currently prescribed a salbutamol inhaler, beclomethasone / formoterol (Fostair) inhaler and theophylline (Slo-Phyllin) 500mg twice daily.    Calculate Mrs TR’s theophylline clearance in L/h.  Give your answer to TWO (2) decimal places.    CL Theo = 0.04 L/kg/h CL multiplication factors:  Smoking: 1.6 COPD: 0.8 

Compared to placebo, DRUG P reduces the rate of fatal cardio…

Compared to placebo, DRUG P reduces the rate of fatal cardiovascular events from 0.09 to 0.07. What is the number needed to treat?   ARC = the absolute risk of events in the control groupART = the absolute risk of events in the treatment groupARR (absolute risk reduction) = ARC – ARTNNT (number needed to treat) = 1 / ARR

You are a pharmacist working in a GP practice. You are under…

You are a pharmacist working in a GP practice. You are undertaking a project to switch all suitable patients from Spiriva Handihaler® to Braltus Zonda®. Spiriva Handihaler® costs £34.87, whilst Braltus Zonda® costs £25.80. There are 78 patients prescribed Spiriva Handihaler®, and 74 patients are deemed suitable to be switched onto Braltus Zonda®. Assuming one inhaler is provided each month, what is the average monthly saving that is achieved by making this change? Give your answer in pounds to the nearest penny.

A dermatologist requests a 200 g preparation of hydrocortiso…

A dermatologist requests a 200 g preparation of hydrocortisone 2 % w/w. You only have a 2.5 % cream available and decide to dilute this with white soft paraffin. How many grams of the 2.5 % cream will be required for you to extemporaneously prepare the required 2 % w/w cream?  

You work in a hospice and see a patient with severe opioid r…

You work in a hospice and see a patient with severe opioid responsive pain. Unfortunately, the patient has been unable to tolerate morphine and oxycodone due to persistent confusion and hallucinations. The palliative care consultant recommends a trial of oral hydromorphone. The patient is currently prescribed oxycodone 40 mg MR tablets at a dose of ONE tablet to be taken TWICE A DAY PO. Using the table below, what dose of hydromorphone would provide an equivalent daily dose? Give your answer in milligrams to the nearest whole number.   Extract from Online BNF