3. How does ischemic cell death cause a fatal response to my…

3. How does ischemic cell death cause a fatal response to myocardial infarction? Relatedly, how can the type I Interferon response be targeted to provide cardioprotection post-myocardial infarction? A. How does release of self-DNA trigger innate immune response upon ischemic cell death? B. How does the IL-1 pathway contribute to post-MI inflammation? C. Describe how IL-1 blockade improves clinical outcomes of heart diseases? D. How does IRF3 and IFNAR deficiency protect against MI?