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You are covering the acute admission unit on a Saturday afternoon, when you hear reports a member of nursing staff has suffered from a needle stick injury. You are approached by the nurse affected asking for your advice on post-exposure prophylaxis (PEP). What advice do you provide to the nurse?

Briefly, discuss the mode of action and selectivity of protease inhibitors (e.g.darunavir) in antiretroviral therapy and explain how the use of a boosted protease regimen (e.g. emtricitabine and tenofovir disproxil with darunavir boosted by ritonavir) can be beneficial to patient treatment.

Which subunit region of the bacterial ribosome do the aminoglycosides target?

A postoperative appendectomy patient has a nasogastric tube and wonders why the previous nurse told him that he was receiving an IV “ulcer-preventing” medication called pantoprazole. The patient states that he has never had any stomach problems in his life. Which is the best response by the nurse?

Both the aminoglycosides (e.g. gentamicin) and tetracyclines (e.g. doxycycline) are antibiotics that target bacterial rRNA. Briefly discuss the mode of action of each indicating spectrums of activity and pathways of common resistance.

The doctor orders a patien to have 1500 mL NS infused over 8 hours, with a drop factor of 15 gtt/mL. What would the drip rate be per minute?

Which drug therapy is aimed at reducing gastric acid secretions? (Select 2 that apply.)

In the management of sepsis, what are considered to be the sepsis 6 care bundle?

Mrs DF, a 78 year old lady, is living in a nursing home and is a known Type 2 diabetic. The staff have noted she has a red area on her left leg that is increasing in size and she is also becoming a little more confused than normal. Her temperature is 38 ⁰C and her BP is 105/60. Mrs DF’s GP attends and make a diagnosis of cellulitis.   How should Mrs DF be manged?

You are a pharmacist prescriber in a primary care centre, when patient Mrs PH presents. Mrs PH is 64 years old and has a cough that has been getting worse over the last 4 days. The cough is productive with thick green sputum. There is no pain associated with the cough; however, Mrs PH states she is feeling a little breathless and a bit worn out. PMH:   • Hypertension   • Meds: Amlodipine 10mg daily   • No allergies   • Ex- smoker (used to smoke 5-10 cigarettes a day but gave up 25 years ago)TEST RESULTS   • Blood pressure: 100/58 mm/Hg   • Pulse: 132 BPM   • Temperature: 38.3 deg C   • Resp rate: 31   • Urea 9mmol/l   • SP02: 93% (a) Interpret Mrs PH’s presenting signs and symptoms.   (3 marks)   (b) Based on Mrs PH’s signs and symptoms, establish what is the likely diagnosis and how should this be managed?   (2 marks)