A 68-year-old female is started on opioid therapy for pain c…

A 68-year-old female is started on opioid therapy for pain control after admission for an automobile accident. Her pain was well controlled until the last 2 days when she developed increased somnolence and decreased respiratory rate, leading to intubation. There were no changes in her medication therapy. Current labs include Na: 135 meq/L; K 5.2 meq/L; Cl: 119 meq/L; BUN: 40; and SCr: 4.5 mg/dL, total bilirubin = 2.4. Which opioid would be the most appropriate to use in this patient?

An open label randomized controlled trial compares inclisira…

An open label randomized controlled trial compares inclisiran 284 mg as a single injection on day 0, 3 months, then every 6 months to alirocumab 150mg every 14 days among patients who have a history of ASCVD and statin intolerance. In the inclisiran arm 10% of patients were on ezetimibe and in the alirocumab arm 15% of patient were on ezetimibe. The rate of major adverse cardiac events among patients using inclisiran compared to alirocumab was 1.13 (95%CI 0.96-1.30). Alirocumab decreased LDL more than inclisiran (36mg/dL versus 24mg/dL, respectively, p-value 0.04). Which of the following statements are true regarding this study? (SELECT ALL THAT APPLY)