The following is correct concerning human immunodeficiency v…

The following is correct concerning human immunodeficiency virus (HIV) resistance to protease inhibitors: (1)1.    High-level resistance occurs to the viral reverse transcriptase enzyme2.    It occurs as an accumulation of stepwise mutations of the viral protease gene3.    It occurs to prevent allosteric inhibition of the viral reverse transcriptase enzyme4.    Resistance occurs when the virus experiences a shift in tropism5.    A single-point mutation occurs within the viral integrase gene