The aldosterone receptor inhibitor spironolactone is conside…

The aldosterone receptor inhibitor spironolactone is considered a potassium-sparing diuretic. Given what you know about the site of aldosterone action in the nephron, which nephron segment(s) and sodium transporter(s) might be affected by spironolactone treatment?

An elderly frail woman has fever, dysuria, nausea, vomiting…

An elderly frail woman has fever, dysuria, nausea, vomiting and flank pain. The urinalysis demonstrates pyuria, white blood cell casts, hematuria, positive leukocyte esterase and gram-negative rods on Gram stain. What should next be done immediately in terms of her medical management?