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Consider the drug Beclomethasone dipropionate shown here. Fill in the blanks below: – This drug has a [blank1] pharmacophore – The “one” in the drug’s name indicates the presence of what type of functional group? [blank2]

Drug Y is an “anti-fungal” agent with BOTH an acidic and basic functional group… The correct generic name for Drug Y is ______.

The drugs acetaminophen (Tylenol), diphenhydramine (Benadryl), and warfarin (Coumadin) all exhibit very different biological and/or pharmacological activity. Therefore, they ______ the same pharmacophore.

Consider the compound Elamipretide shown here. ENTER A, B, C, D, E or NONE to complete the blanks… *** a) Region(s) [blank1] is/are considered polar *** b) Region(s) [blank2] is/are considered lipophilic *** c) Region(s) [blank3] include(s) the amino acid Valine *** d) Region(s) [blank4] include(s) the amino acid Phenylalanine *** e) Region(s) [blank5] will ionize greater than 50% at pH 7.4 SHORT ANSWER… *** f) What types of bonds present in Elamipretide would readily hydrolyze under acidic conditions? Briefly explain… [blank6] *** g) What would the NET CHARGE be on Elamipretide at physiolgical pH, 7.4? Briefly explain… [blank7]

Select the amino acid(s) that contain an IONIZABLE SIDE CHAIN (under physiological conditions)? (select all that apply)

Consider Drug S in the figure below. Which functional group is most sensitive to ACID DEGRADATION?

Select the amino acid(s) that contain a POLAR SIDE CHAIN? (select all that apply)

The following statements are ALL FALSE. CORRECT THE STATEMENTS *** Alkaloids like quinine are biologically active amine-containing compounds typically found in animals [blank1] *** The DNA/RNA base shown here is categorized as a pyrimidine [blank2] *** The functional groups show here is acidic under physiological conditions [blank3] R-O-R’ *** The drug shown below is the sodium salt of penicillin [blank4]

Refer to Drug Y for this question. Determine if the statements regarding Drug Y are either TRUE or FALSE.  

Recalling discussions regarding “what’s in a drug name?”, of the functional groups listed below, select the group(s) that are likely to be present in a drug named CHLORAMPHENICOL? (select all that apply)