A patient with diabetes was recommended to initiate canaglif…

A patient with diabetes was recommended to initiate canagliflozin for blood glucose control. The patient is at high risk for stroke and asks if canagliflozing may increase their risk for stroke. You perform a literature search and find a RCT that compared canagliflozing to placebo for cardiovascular outcomes. It found the rate of stroke to be 7.9% in the canagliflozin group and 9.6% in the placebo group (HR 0.87, 95%CI 0.69–1.09). Match the appropriate language to describe this data to the intended audience.

A RCT compared eptinezumab (a new CGRP antagonist) to topira…

A RCT compared eptinezumab (a new CGRP antagonist) to topiramate for migraine prevention using an NI margin of 0.5 monthly migraine days. The mean decrease in monthly migraine days with eptinesumab was 3.9 days and with topiramate was 4.1 days (mean difference 0.2 days; 95%CI -0.02 to 0.42). Which of the following statements is the best interpretation of the results?