ANTIFUNGALS … Antifungal drugs exploit the biochemical diffe…

ANTIFUNGALS … Antifungal drugs exploit the biochemical differences between healthy cells and infected cell. *** a) The “azole” class of antifungal drugs, function by inhibiting the production of what sterol that is unique to fungi? [blank1] *** b) What is the sterol found in normal mammalian cell membranes? [blank2] *** c) Consider the portion of the biosynthesis pathway for a key component of the fungal membrane … What type of enzyme is responsible for this reaction? [blank7] *** d) Name an antifungal “azole” drug discussed in class. [blank3] *** e) What metal element are these drugs attracted to in the active sites of fungal enzymes (hint: and also P450s)? [blank4] *** f)  Consider the portion of the biosynthesis pathway for a key component of the fungal membrane … What type of enzyme is responsible for this reaction?  [blank5] *** g) Would the reaction shown above be classified as a Phase I or Phase II type reaction? [blank6]