The multidrug membrane transporter P-Glycoprotein (PGP) is t…

The multidrug membrane transporter P-Glycoprotein (PGP) is the best-studied ABC family transporter found to function in multidrug resistance.  (A) What are PGP’s normal “good” functions in our body? (3 pts.) (B) What is the evidence that this function is coopted (diverted to a role different from the original one) by cancer cells to protect themselves from anticancer drugs? (2 pts.) Integral membrane proteins have at least one portion of the protein that exists within the lipid bilayer. (C) Diagram and describe two ways transmembrane proteins can be amphipathic and how it is an important property for their function. (3 pts.) (D) Diagram and describe the difference between the hydropathy plots of the transmembrane protein types. (3 pts.) (E) Diagram, describe, and compare: passive, primary active and secondary active transmembrane transport. (4 pts.)