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Why would the inability to grow, in pure culture, the bacterium you suspect is the cause of an infectious disease make proving your hypothesis according Koch’s Postulates difficult?

A new antiviral drug has been designed that inhibits all known virally-produced, RNA-dependent RNA polymerases. This drug would be expected to interfere with the replication of all of the following viruses EXCEPT:

Of the following toxin categories, which would Botulinum and Tetanospasmin toxin fall under?

Which of the following vaccines would NOT be effective in preventing meningitis?

Ocular infections are LEAST likely as the result of exposure to:

A patient attends clinic after being becoming aggressive with mental health workers following a violent episode at work. The patient also exhibits photophobia and hydrophobia. Upon his death, autopsy reveals substantial numbers of dead neurons and oligodendrocytes (supporting cells of the brain).  What pathogen was most likely responsible for his demise?

Intoxications would be expected to have:

A patient exhibiting a textbook definition of meningitis attends hospital, where nucleic acid amplification tests identify the presence of a single stranded, positive-sense RNA virus in his cerebrospinal fluid (CSF). Identify the pathogen most likely to be responsible for his disease?

An individual attends clinic exhibiting the production of a rusty (bloody) sputum and cough, but never develops pneumonia. What pathogen is most likely to be responsible?

A patient attends an STD clinic complaining of “things growing down there”. Physical examination by yourself and your partner, a 1st year medical student from Fancipants University Medical School, reveal the presence of moist, flat lesions that are neither serous (fluid blisters) nor purulent. You identify the lesions as condylomata lata, but your partner is convinced the lesions are due to HSV-2 infection. Why is your diagnosis better?