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metabolic changes are not a promising avenue for design of anticancer therapies.

Questions 54-58 According to the model for nuclear transport, what do you think would happen if you could artificially limit all Ran-GAP activity to the nucleus and all Ran-GEF activity to the cytosol?

provides cancer cells the ability to live on glucose alone.

Proteins containing an NLS would be actively exported from the nucleus, while NES-containing proteins would be actively imported.

the Na+–amino acid symporters in the apical domain of the plasma membrane.

continue to pump ions without hydrolyzing ATP.

is mediated by microtubule transport directed to the basolateral versus the apical plasma membranes.

Questions 44-48 Nuclear-cytoplasmic transport

is catalyzed by import and export receptor-FG repeat interactions through the nuclear pore complex.

(A) Diagram the structure of the nucleus. Indicate the aspects important for nuclear-cytoplasmic compartmentalization and transport. (2 pts.) (B) Diagram the general structure of the nuclear pore complex. (2 pts.) (C) Diagram the functional role of the phenylalanine-glycine repeats (FG repeats) in facilitating the passage of nuclear import/export receptor passage through the nuclear pore complex.  Do the FG repeats function to change the