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There are 35 multiple choice/short answer/fill in the blank (2pts ea) in this section of the exam.

The Jewish holy book is the

One of the most significant accomplishments of Hammurabi was the

Consider the drug Beclomethasone dipropionate shown here. Fill in the blanks below: – This drug has a [blank1] pharmacophore – The “one” in the drug’s name indicates the presence of what type of functional group? [blank2]

Drug Y is an “anti-fungal” agent with BOTH an acidic and basic functional group… The correct generic name for Drug Y is ______.

The drugs acetaminophen (Tylenol), diphenhydramine (Benadryl), and warfarin (Coumadin) all exhibit very different biological and/or pharmacological activity. Therefore, they ______ the same pharmacophore.

Consider the compound Elamipretide shown here. ENTER A, B, C, D, E or NONE to complete the blanks… *** a) Region(s) [blank1] is/are considered polar *** b) Region(s) [blank2] is/are considered lipophilic *** c) Region(s) [blank3] include(s) the amino acid Valine *** d) Region(s) [blank4] include(s) the amino acid Phenylalanine *** e) Region(s) [blank5] will ionize greater than 50% at pH 7.4 SHORT ANSWER… *** f) What types of bonds present in Elamipretide would readily hydrolyze under acidic conditions? Briefly explain… [blank6] *** g) What would the NET CHARGE be on Elamipretide at physiolgical pH, 7.4? Briefly explain… [blank7]

Select the amino acid(s) that contain an IONIZABLE SIDE CHAIN (under physiological conditions)? (select all that apply)

Consider Drug S in the figure below. Which functional group is most sensitive to ACID DEGRADATION?

Select the amino acid(s) that contain a POLAR SIDE CHAIN? (select all that apply)