Blog

A defect in the enzyme glucose-6-phosphatase has severe consequences on which of the following?

CASE 4: (There will be 8 questions on this case) A canine patient presents with a history of polyuria (frequent urination), polydipsia (frequent drinking) and vomiting. Physical findings include a > 5% dehydration, apparent disorientation and Kussmaul respirations (rapid, deep breathing). Blood work reveals elevated blood glucose (> 300 mg/dL), severe ketoacidosis (very high ketone levels and acidosis) and non-detectable insulin levels. You make a diagnosis of severe diabetic ketoacidosis (DKA) secondary to type I diabetes. CASE 4, Q1: In this patient, liver gluconeogenesis is…

CASE 4, Q5: β-oxidation is stimulated due to…

A drug which blocks (inhibits) opening of the ATP-sensitive K+ channel would increase insulin secretion.

Which of the following is a mechanism underlying the loss of β-cells during late stage non-insulin dependent diabetes (NIDDM) in cats and humans?

Coenzymes often contain vitamins.

During high milk production, dairy cattle can develop “bovine ketosis”, characterized by hypoglycemia (low blood glucose). What is a primary reason ketone production is high?

CASE 4, Q6: This patient also has high levels of free fatty acids (FFA) in the blood which are metabolized by the liver. Why are circulating FFA increased?

Select the best conclusion based on the graph depicting the relationship between serum ketones and serum insulin concentration. 

You need to deliver a very large gene that requires very high, but transient expression in all cells. However, because of this you only need to do one injection rather than repeated injections. Which of the following would be the best delivery system in this scenario: