Phosphatidylinositol glycan A (PIGA)  is required for the me…

Phosphatidylinositol glycan A (PIGA)  is required for the membrane attachment of proteins anchored by glycolipids to the plasma membrane, using what is called a ‘GPI-linkage.’ Included in the group of GPI-linked cell surface proteins is DAF/CD55. Individual lacking the GPI linkage become anemic because:

When macrophages in a tissue encounter bacteria, they releas…

When macrophages in a tissue encounter bacteria, they release cytokines that induce an inflammatory response. These cytokines act on other immune cells, to recruit them to the site of infection and to enhance their activities. In addition, these cytokines act on the endothelial cells of the blood vessel wall to: